Myeloperoxidase Predicts Progression of Carotid Stenosis in States of Low High-Density Lipoprotein Cholesterol
Markus Exner, MD*,
Erich Minar, MD ,
Wolfgang Mlekusch, MD,
Schila Sabeti, MD,
Jasmin Amighi, MD,
Wolfgang Lalouschek, MD ,
Gerald Maurer, MD ,
Christian Bieglmayer, PhD*,
Heidi Kieweg*,
Oswald Wagner, MD* and
Martin Schillinger, MD,*
* Departments of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Vienna, Austria
Department of Angiology, Medical University Vienna, Vienna, Austria
Department of Neurology, Medical University Vienna, Vienna, Austria
Department of Cardiology, Medical University Vienna, Vienna, Austria
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Figure 1 Frequency of patients with progression of carotid artery disease, measured by duplex ultrasound, according to myeloperoxidase (MPO, in quartiles) and high-density lipoprotein (HDL, in quartiles) levels.
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Figure 2 Forrest plot describing the risk for progression of carotid atherosclerosis by duplex ultrasound from baseline to follow-up after median 7.5 months (interquartile range 6 to 9 months) calculated by multivariable logistic regression analysis. Models adjusted for age, gender, body mass index, family history of atherosclerotic disease, hypertension, current smoking, glycated hemoglobin A1, low-density lipoprotein cholesterol, serum creatinine, history of myocardial infarction, history of stroke, stain therapy, and baseline degree of carotid atherosclerosis. CI = confidence interval; HDL = high-density lipoprotein; MPO = myeloperoxidase.
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