HOME SUBSCRIPTIONS CURRENT ISSUE PAST ISSUES CARDIOSOURCE SEARCH HELP FEEDBACK		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jiménez-Quevedo, P. Search for Related Content PubMed PubMed Citation Articles by Jiménez-Quevedo, P.

Vascular Effects of Sirolimus-Eluting Versus Bare-Metal Stents in Diabetic Patients

Three-Dimensional Ultrasound Results of the Diabetes and Sirolimus-Eluting Stent (DIABETES) Trial

Pilar Jiménez-Quevedo, MD^_*,1, Manel Sabaté, MD, PhD^_*,_*, Dominick J. Angiolillo, MD, Marco A. Costa, MD, PhD, Fernando Alfonso, MD, PhD^_*, Joan Antoni Gómez-Hospital, MD, PhD, Rosana Hernández-Antolín, MD, PhD^_*, Camino Bañuelos, MD^_*, Javier Goicolea, MD, PhD, Francisco Fernández-Avilés, MD, PhD^||, Theodore Bass, MD^_*,,,,||, Javier Escaned, MD, PhD^_*, Raul Moreno, MD^_*, Cristina Fernández, MD, PhD^_*, Carlos Macaya, MD, PhD^_* for the DIABETES Investigators

^_* San Carlos University Hospital, Madrid, Spain
University of Florida Cardiovascular Imaging Core Laboratories, Jacksonville, Florida
"Prínceps d’Espanya" University Hospital, Barcelona, Spain
"Do Meixoeiro" University Hospital, Vigo, Spain
^|| Clínico University Hospital, Valladolid, Spain

View larger version (31K): [in a new window]   Figure 1 (Top panels) Histograms of neointima hyperplasia (NIH) volume in the sirolimus-eluting stent (SES) group (left) and the bare-metal stent (BMS) group (right). A non-Gaussian distribution is demonstrated in both groups (Kolmogorov-Smirnov test: p < 0.0001 for SES group; p = 0.02 for BMS group). The median test evidenced significant differences between groups. (Bottom panels) Histograms of percent volume obstruction in the SES group (left) and the BMS group (right). A non-Gaussian distribution is demonstrated in both groups (Kolmogorov-Smirnov test: p < 0.0001 for SES group; = 0.03 for BMS group). The median test evidenced significant differences between groups.

View larger version (30K): [in a new window]   Figure 2 Patterns of vascular changes at proximal (top panels) and distal edges (bottom panels). In the bare-metal stent group (left), negative remodeling (reduction in external elastic membrane [EEM] volume), led to a reduction in luminal volume despite small reductions in plaque volume. In the sirolimus-eluting stent group (right), vessel enlargement (increase in EEM volume) encompassed an increase in plaque volume, resulting in a net gain in lumen volume. *p = 0.09; p = 0.04; p = 0.05; p = 0.001; ¶p = 0.03 (post-procedure versus 9-month follow-up p values).

View larger version (117K): [in a new window]   Figure 3 (Top) Intravascular imaging of a stent completely apposed immediately after the implantation. (Bottom) Same artery imaging at nine-month follow-up: Late acquired incomplete stent apposition is evidenced.