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Atrial Fibrillation and Risk of Clinical Events in Chronic Heart Failure With and Without Left Ventricular Systolic Dysfunction

Results From the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) Program

Lars G. Olsson, MB^_*, Karl Swedberg, MD, PhD, FACC^_*,1,_*, Anique Ducharme, MD, MSc^,5, Christopher B. Granger, MD, FACC^,2, Eric L. Michelson, MD, FACC^,4, John J.V. McMurray, MD, FACC^||,1, Margareta Puu, PhD^¶,4, Salim Yusuf, MD, DPhil, FACC^#,3, Marc A. Pfeffer, MD, PhD, FACC^_**,1 on behalf of the CHARM Investigators

^_* Department of Medicine, Sahlgrenska University Hospital/Östra, Göteborg, Sweden
Research Center, Montreal Heart Institute, Montreal, Quebec, Canada
Duke University Medical Center, Durham, North Carolina
AstraZeneca LP, Wilmington, Delaware
^|| Department of Cardiology, Western Infirmary, Glasgow, Scotland
^¶ AstraZeneca, Mölndal, Sweden
^# HGM-McMaster Clinic, Hamilton, Ontario, Canada
^_** Brigham and Women’s Hospital, Boston, Massachusetts.

View larger version (27K): [in a new window]   Figure 1 Risk of baseline atrial fibrillation (AF) for cardiovascular (CV) events depending on ejection fraction (EF). CHF = chronic heart failure.

View larger version (23K): [in a new window]   Figure 2 Time to cardiovascular (CV) death or hospitalization because of heart failure. AF = atrial fibrillation; EF = ejection fraction; PEF = preserved left ventricular ejection fraction.

View larger version (22K): [in a new window]   Figure 3 Time to all-cause mortality. AF = atrial fibrillation; CI = confidence interval; EF = ejection fraction; PEF = preserved left ventricular ejection fraction.

View larger version (28K): [in a new window]   Figure 4 Risk of new-onset atrial fibrillation (AF) for cardiovascular (CV) events depending on ejection fraction (EF). CHF = chronic heart failure.

View larger version (23K): [in a new window]   Figure 5 Treatment effects depending on baseline heart rhythm in CHARM-Overall. AF = atrial fibrillation; CHF = chronic heart failure; CV = cardiovascular.