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Relationship Between Cardiovascular Risk Factors and Atherosclerotic Disease Burden Measured by Intravascular Ultrasound

Stephen J. Nicholls, MBBS, PhD^_*,1,4, E. Murat Tuzcu, MD^_*,3,4, Tim Crowe, BS^_*, Ilke Sipahi, MD^_*,2, Paul Schoenhagen, MD^_*, Samir Kapadia, MD^_*, Stanley L. Hazen, MD, PhD^_*,3,4, Chuan-Chuan Wun, PhD, Michele Norton, PhD, Fady Ntanios, PhD and Steven E. Nissen, MD^_*,3,4,_*

^_* Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio
Pfizer Pharmaceuticals, New York, New York

View larger version (105K): [in a new window]   Figure 1 Method for selection of cross sections for analysis. Cross sections are obtained for "slices" selected at 1-mm intervals (top). Three of the 48 cross sections illustrated for this vessel are shown at the bottom (cross sections 10, 26, and 48).

View larger version (91K): [in a new window]   Figure 2 Method for analysis of atheroma area. The left panel shows a representative intravascular ultrasound cross section. The right panel illustrates the boundaries planimetered for the external elastic membrane (EEM) and lumen. Atheroma area is calculated.