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Factors Influencing Appropriate Firing of the Implanted Defibrillator for Ventricular Tachycardia/Fibrillation

Findings From the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)

Jagmeet P. Singh, MD, PhD^_*,_*, W. Jackson Hall, PhD, Scott McNitt, MS, Hongyue Wang, MA, James P. Daubert, MD, Wojciech Zareba, MD, Jeremy N. Ruskin, MD^_*, Arthur J. Moss, MD and the MADIT-II Investigators

^_* Cardiac Arrhythmia Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York
Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York

View larger version (22K): [in a new window]   Figure 1 Kaplan-Meier curves for the probability of receiving appropriate implantable cardioverter-defibrillator (ICD) therapy in patients after interim hospitalization for congestive heart failure (CHF) (Post CHF) compared with a period before any such hospitalization (Pre CHF). Panels A and B show the curves for combined ventricular tachycardia (VT) and ventricular fibrillation (VF) (with censoring at death), and for combined VT, VF, and death, respectively.

View larger version (22K): [in a new window]   Figure 2 Kaplan-Meier curves for the probability of receiving appropriate implantable cardioverter-defibrillator (ICD) therapy in patients after interim hospitalization for coronary events (Post IH-CE) compared with the period before any such hospitalization (Pre IH-CE). Panels A and B show the curves for combined ventricular tachycardia (VT) and ventricular fibrillation (VF) (with censoring at death), and for combined VT, VF, and death, respectively.

View larger version (22K): [in a new window]   Figure 3 Kaplan-Meier curves for receiving implantable cardioverter-defibrillator (ICD) therapy in patients after interim hospitalization for heart failure (Post CHF) in patients sub-stratified by New York Heart Association (NYHA) functional class. Panel A shows that patients with NYHA class II have a higher propensity to receive ICD therapy after hospitalization, as opposed to an absence of this effect in patients with NYHA class III or IV function (B). Other abbreviations as in Figures 1 and 2.