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Granulocyte Colony-Stimulating Factor and Stem Cell Factor Improve Contractile Reserve of the Infarcted Left Ventricle Independent of Restoring Muscle Mass

Casilde Sesti, PhD^_*, Sharon L. Hale, BS^_*, Carolyn Lutzko, PhD and Robert A. Kloner, MD, PhD^_*,_*

^_* Heart Institute, Good Samaritan Hospital, Cardiovascular Division, Keck School of Medicine at the University of Southern California, Los Angeles, California
Children’s Hospital-Los Angeles, Los Angeles, California

View larger version (23K): [in a new window]   Figure 1 Left ventricular (LV) end-diastolic and systolic volumes in control (open bars) and treated rats (solid bars) under resting and stress conditions. During stress, volumes were smaller in the treated group. *p < 0.05 versus control.

View larger version (17K): [in a new window]   Figure 2 Correlation between ejection fraction at rest and infarct size, expressed as percent of left ventricular area. Ejection fraction, for any infarct size, was significantly greater in the treated group (closed circles and solid line) than in the control group (open circles and dotted line). Statistical analysis by analysis of covariance.

View larger version (18K): [in a new window]   Figure 3 Correlation between left ventricular (LV) end-diastolic (A) and LV end-systolic (B) volumes under stress and infarct size, expressed as percent of LV area. Both parameters, LV end-diastolic and LV end-systolic volumes, for any infarct size were significantly smaller in treated animals (closed circles) than in control animals (open circles). Statistical analysis by analysis of covariance.

View larger version (111K): [in a new window]   Figure 4 Picrosirius red-stained sections of control (A,B) and treated (C,D) hearts. Muscle cells appear yellow, scar tissue appears red. (A and C) Original magnification x40. (B and D) Higher magnification x200 of the area indicated by rectangle in panels A and C, respectively. The morphology in the two groups is similar without evidence of newly formed muscle in the treated hearts.