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C-Reactive Protein Increase in Unstable Coronary Disease

Cause or Effect?

Stefano De Servi, MD, FESC^_*,_*, Matteo Mariani, MD^_*, Giuseppe Mariani, MD^_* and Antonino Mazzone, MD

^_* Department of Cardiovascular Disease, Ospedale Civile di Legnano, Legnano (Milan), Italy
Department of Internal Medicine, Ospedale Civile di Legnano, Legnano (Milan), Italy

View larger version (16K): [in a new window]   Figure 1 Relationship between C-reactive protein (CRP) and troponin values in 7,108 patients included in the GUSTO IV trial. Data from James et al. (28).

View larger version (14K): [in a new window]   Figure 2 Death (left) and myocardial infarction (MI) rate (right) according to increasing values of C-reactive protein (CRP) and troponin in 7,108 patients included in the GUSTO IV trial. qrtl. = quartile. Data from James et al. (28).

View larger version (12K): [in a new window]   Figure 3 Levels of C-reactive protein (CRP) increase in patients with acute coronary syndromes (ACS) as compared with their baseline levels. This increase, as well as the variability, is greater for hyperresponsive patients, who are those with elevated CRP values at baseline; see text for details.