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Can Low-Density Lipoprotein Be Too Low? The Safety and Efficacy of Achieving Very Low Low-Density Lipoprotein With Intensive Statin Therapy

A PROVE IT-TIMI 22 Substudy

Stephen D. Wiviott, MD^_*,,_*, Christopher P. Cannon, MD, FACC^_*,, David A. Morrow, MD, MPH, FACC^_*,, Kausik K. Ray, MD, Marc A. Pfeffer, MD, PhD, FACC^_*, Eugene Braunwald, MD, MACC^_*, for the PROVE IT-TIMI 22 Investigators

^_* Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts
The TIMI Study Group, Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts

View larger version (17K): [in a new window]   Figure 1 Distribution of four-month calculated low-density lipoprotein (LDL) (mg/dl) levels among subjects treated with intensive statin therapy (atorvastatin, 80 mg).

View larger version (13K): [in a new window]   Figure 2 Hazard ratio of the primary end point compared with achieved calculated low-density lipoprotein (LDL) 80 to 100 mg/dl (adjusted for age, gender, baseline calculated low-density lipoprotein, diabetes mellitus, and prior myocardial infarction).