Can Low-Density Lipoprotein Be Too Low? The Safety and Efficacy of Achieving Very Low Low-Density Lipoprotein With Intensive Statin Therapy
A PROVE IT-TIMI 22 Substudy
Stephen D. Wiviott, MD*, ,*,
Christopher P. Cannon, MD, FACC*, ,
David A. Morrow, MD, MPH, FACC*, ,
Kausik K. Ray, MD ,
Marc A. Pfeffer, MD, PhD, FACC*,
Eugene Braunwald, MD, MACC*, for the PROVE IT-TIMI 22 Investigators
* Cardiovascular Division, Brigham and Womens Hospital, Boston, Massachusetts
The TIMI Study Group, Cardiovascular Division, Brigham and Womens Hospital, Boston, Massachusetts

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Figure 1 Distribution of four-month calculated low-density lipoprotein (LDL) (mg/dl) levels among subjects treated with intensive statin therapy (atorvastatin, 80 mg).
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Figure 2 Hazard ratio of the primary end point compared with achieved calculated low-density lipoprotein (LDL) 80 to 100 mg/dl (adjusted for age, gender, baseline calculated low-density lipoprotein, diabetes mellitus, and prior myocardial infarction).
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