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The Extent of Perfusion–F18-Fluorodeoxyglucose Positron Emission Tomography Mismatch Determines Mortality in Medically Treated Patients With Chronic Ischemic Left Ventricular Dysfunction

Alessandro Desideri, MD, FACC^_*,_*, Lauro Cortigiani, MD^_*, Alejandra Ines Christen, MD^_*, Sebastian Coscarelli, MD^_*, Dario Gregori, PhD, Pierluigi Zanco, MD, Roman Komorovsky, MD^_* and Jeroen J. Bax, MD

^_* Cardiovascular Research Foundation, "S. Giacomo" Hospital, Castelfranco Veneto, Italy
Department of Public Health and Microbiology, University of Torino, Torino, Italy
PET Center, Nuclear Medicine Department, "S. Giacomo" Hospital, Castelfranco Veneto, Italy
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands

View larger version (13K): [in a new window]   Figure 1 Kaplan-Meier survival curve with 95% confidence intervals in the medically treated patients; the number of patients at risk at the different time-intervals is indicated.

View larger version (7K): [in a new window]   Figure 2 Plot of log-hazard versus mismatch (MM) in non-linear terms. The graph indicates a non-significant effect on risk of having a mismatch with an extent 20% compared with 0% (hazard ratio [HR] 0.97, 95% confidence interval [CI] 0.46 to 2.05), whereas the effect is significant when the extent of mismatch exceeds 20% (HR 3.21, 95% CI 1.38 to 7.49).