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Aspirin Administered at Bedtime, But Not on Awakening, Has an Effect on Ambulatory Blood Pressure in Hypertensive Patients

Ramón C. Hermida, PhD^_*,_*, Diana E. Ayala, MD, PhD^_*, Carlos Calvo, MD, PhD and José E. López, MD, PhD

^_* Department of Bioengineering and Chronobiology Laboratories, University of Vigo, Campus Universitario, Vigo, Spain
Hypertension and Vascular Risk Unit, Hospital Clínico Universitario, Santiago de Compostela, Spain

View larger version (41K): [in a new window]   Figure 1 Changes in blood pressure (BP), heart rate, and wrist activity after three months of hygienic-dietary intervention in patients with mild hypertension sampled by 48-h ambulatory monitoring. Each graph shows hourly means and standard errors of data collected before (continuous line) and after (dashed line) three months of nonpharmacological intervention. Dark shading along the lower horizontal axis of the graphs represents average hours of nocturnal sleep across the patients.

View larger version (44K): [in a new window]   Figure 2 Changes in blood pressure (BP), heart rate, and wrist activity after aspirin (100 mg/day) administered on awakening in patients with mild hypertension sampled by 48-h ambulatory monitoring. Each graph shows hourly means and standard errors of data collected before (continuous line) and after (dashed line) three months of aspirin administration. Dark shading along the lower horizontal axis of the graphs represents average hours of nocturnal sleep across the patients. *p < 0.05 from t test adjusted for multiple testing.

View larger version (44K): [in a new window]   Figure 3 Changes in blood pressure (BP), heart rate, and wrist activity after aspirin (100 mg/day) administered before bedtime in patients with mild hypertension sampled by 48-h ambulatory monitoring. Each graph shows hourly means and standard errors of data collected before (continuous line) and after (dashed line) three months of aspirin administration. Dark shading along the lower horizontal axis of the graphs represents average hours of nocturnal sleep across the patients. *p < 0.05 from t test adjusted for multiple testing.