Genetic Polymorphism on Endothelial Nitric Oxide Synthase Affects Endothelial Activation and Inflammatory Response During the Acute Phase of Myocardial Infarction
Charalambos Antoniades, MD,
Dimitris Tousoulis, MD, PhD, FACC*,
Carmen Vasiliadou, BSc, MSc,
Christos Pitsavos, MD, FACC, FESC,
Christina Chrysochoou, MD,
Demosthenis Panagiotakos, BSc, MSc, PhD,
Costas Tentolouris, MD, FACC, FESC,
Kyriakoula Marinou, MD,
Nikolaos Koumallos, MD and
Christodoulos Stefanadis, MD, PhD, FACC, FESC
Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
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p < 0.05 and 
p < 0.01 vs. acute phase; 
p < 0.05 vs. matched control patients (adjusted according to Bonferoni). (b) Serum levels of oxidized LDL (ox-LDL) were significantly higher during the acute phase of myocardial infarction in patients with GT+TT (open squares) compared with those with GG (filled diamonds) genotype (p < 0.05). Serum oxidized low-density lipoprotein (LDL) was not significantly different in GT+TT compared with GG in patients one year after the event or in matched control patients (p = NS). Values are expressed as mean ± SEM. *p < 0.05 vs. GG; 