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Genetic Polymorphism on Endothelial Nitric Oxide Synthase Affects Endothelial Activation and Inflammatory Response During the Acute Phase of Myocardial Infarction

Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece

View larger version (17K): [in a new window]   Figure 1 (a) Plasma levels of von Willebrand factor (vWF) were significantly higher during the acute phase of myocardial infarction in patients with GT+TT (open squares) compared with those with GG (filled diamonds) genotype (p < 0.01). One year after the event, plasma vWF was still higher in GT+TT compared with GG (p < 0.05), but there was no significant difference in vWF levels between genotypes in the control group (p = NS). Values are expressed as mean ± SEM. *p < 0.05 and **p < 0.01 vs. GG; p < 0.05 and p < 0.01 vs. acute phase; p < 0.05 vs. matched control patients (adjusted according to Bonferoni). (b) Serum levels of oxidized LDL (ox-LDL) were significantly higher during the acute phase of myocardial infarction in patients with GT+TT (open squares) compared with those with GG (filled diamonds) genotype (p < 0.05). Serum oxidized low-density lipoprotein (LDL) was not significantly different in GT+TT compared with GG in patients one year after the event or in matched control patients (p = NS). Values are expressed as mean ± SEM. *p < 0.05 vs. GG; p < 0.05 and p < 0.01 vs. acute phase; ap < 0.05 vs. matched control patients (adjusted according to Bonferroni).

View larger version (15K): [in a new window]   Figure 2 (a) Serum levels of interleukin (IL)-6 were significantly higher during the acute phase of myocardial infarction in patients with GT+TT (open squares) compared with those with GG (filled diamonds) genotype (p < 0.05). Serum IL-6 was not significantly different in GT+TT compared with GG in patients one year after the event or in control patients (p = NS). Values are expressed as mean ± SEM. *p < 0.05 vs. GG; p < 0.01 vs. acute phase; p < 0.05 vs. matched control patients (adjusted according to Bonferoni). (b) Serum levels of interleukin-1b (IL-1b) were significantly higher during the acute phase of myocardial infarction compared with one year later (p < 0.01 for all genotypes), but there was no significant difference between patients with GT+TT (open squares) and GG (filled diamonds) genotype (p = NS). Serum IL-1b was not significantly different in GT+TT compared with GG in patients one year after the event or in matched control patients (p = NS). Values are expressed as mean ± SEM. p < 0.01 vs. acute phase; ap < 0.01 vs. matched control patients (adjusted according to Bonferroni).