Myocardial Expression of Fas and Recovery of Left Ventricular Function in Patients With Recent-Onset Cardiomyopathy
Richard Sheppard, MD*,
Maninder Bedi, MD ,
Toru Kubota, MD, PhD ,
Marc J. Semigran, MD ,
William Dec, MD,
Richard Holubkov, PhD||,
Arthur M. Feldman, MD, PhD¶,
Warren D. Rosenblum, MD#,
Charles F. McTiernan, PhD,
Dennis M. McNamara, MD,* for the IMAC Investigators
* McGill University, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Canada
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Cardiovascular Medicine, Kyushu University, Fukuoka, Japan
Massachusetts General Hospital, Boston, Massachusetts
|| Department of Family and Preventive Medicine, School of Medicine, University of Utah, Salt Lake City, Utah
¶ Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania
# New York Medical College, Valhalla, New York
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Figure 1 Relationship between baseline myocardial tumor necrosis factor (TNF)-alpha and Fas gene expression, noted as percent glyceraldehydes 3-phosphate dehydrogenase (GAPDH) expression. Correlation of Fas and TNF expression: r = 0.76, p < 0.01.
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Figure 2 Box plot of distribution change in left ventricular ejection fraction (LVEF) at six months by tertiles of baseline Fas expression. Solid black lines = median; rectangles = quartile range; whiskers = total range. Higher Fas expression is associated with less improvement in LVEF at six months, p = 0.006.
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Figure 3 Change in left ventricular ejection fraction (LVEF) at 12 months by tertiles of baseline Fas expression. Higher Fas expression is associated with less improvement in LVEF at 12 months, p = 0.004.
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Figure 4 Change in left ventricular ejection fraction (LVEF) at 12 months by tertiles of baseline tumor necrosis factor receptor 1 (TNFR1) expression. Higher TNFR1 expression is associated with less improvement in LVEF at six months, p = 0.023.
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Figure 5 Change in left ventricular ejection fraction (LVEF) at 12 months by tertiles of baseline Fas expression. Solid black lines = median; rectangles = quartile range; whiskers = total range excluding outlier; filled circle = outlier. Higher Fas expression is associated with less improvement in LVEF at 12 months, p = 0.011. TNFR1 = tumor necrosis factor receptor 1.
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