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The FRONTIER Stent Registry

Safety and Feasibility of a Novel Dedicated Stent for the Treatment of Bifurcation Coronary Artery Lesions

Thierry Lefèvre, MD^_*,_*, John Ormiston, MD, Giulio Guagliumi, MD, Heinz-Peter Schultheiss, MD, Laurent Quilliet, MD^||, Bernhard Reimers, MD^¶, Philippe Brunel, MD^#, Williams Wijns, MD^**, H.J. Buettner, MD, F. Hartmann, MD, Susan Veldhof, RN, Karin Miquel, PhD, Xiaolu Su, MS and Willem J. van der Giessen, MD^||||

^_* Institut Jacques Cartier, Massy, France
Green Lane/Mercy Hospital, Auckland, New Zealand
Ospedali Riuniti, Bergamo, Italy
Hospital Benjamin Franklin, Berlin, Germany
^|| Hopital Trousseau, Tours, France
^¶ Ospedale Civile, Mirano, Italy
^# Clinique St Henri, Nantes, France
^** OLVG Aalst, Aalst, Belgium
Herz-Zentrum, Bad Krozingen, Germany
Universitatsklinikum Lubeck, Lubeck, Germany
Guidant Europe, Diegem, Belgium
^|||| Erasmus Medical Centre, Rotterdam, the Netherlands

View larger version (81K): [in a new window]   Figure 1 (A to E) Deployment sequence of the Frontier stent. (A) The system is advanced into the main branch over a conventional rapid-exchange wire. (B) The joining mandrel is retracted to release the over-the-wire side branch tip. A long guidewire is inserted into the side branch. (C) The system is advanced up to the carina. (D) With a single inflation device, the stent is deployed by kissing balloon inflation. (E) After deflation the delivery system is retracted.

View larger version (17K): [in a new window]   Figure 2 Bifurcation lesion classification from the Duke University Angiographic Core Lab, Duke University, Durham, North Carolina. Type A: Prebranch stenosis not involving the ostium of the side branch. Type B: Postbranch stenosis of the parent vessel not involving the origin of the side branch. Type C: Stenosis encompassing the side branch but not involving the ostium. Type D: Stenosis involving the parent vessel and ostium of the side branch. Type E: Stenosis involving the ostium of the side branch. Type F: Stenosis directly involving the parent vessel and ostium of the side branch.

View larger version (18K): [in a new window]   Figure 3 Kaplan-Meier curves: survival to 180 days, survival free of major adverse cardiac events (MACE), myocardial infarction (MI), and target lesion revascularization (TLR) (intent-to-treat population).