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Long-Term Effects of Surgical Septal Myectomy on Survival in Patients With Obstructive Hypertrophic Cardiomyopathy

Steve R. Ommen, MD, FACC^_*,_*, Barry J. Maron, MD, FACC^_*,, Iacopo Olivotto, MD, Martin S. Maron, MD^||, Franco Cecchi, MD, Sandro Betocchi, MD, FACC^¶, Bernard J. Gersh, MB, ChB, DPhil, FACC^_*, Michael J. Ackerman, MD, PhD, FACC^_*, Robert B. McCully, MB, ChB, FACC^_*, Joseph A. Dearani, MD, Hartzell V. Schaff, MD, FACC, Gordon K. Danielson, MD, FACC, A. Jamil Tajik, MD, FACC^_* and Rick A. Nishimura, MD, FACC^_*

^_* Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota
Cardiac Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota
Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota
Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Careggi, Florence, Italy
^|| Hypertrophic Cardiomyopathy Center, Division of Cardiology, Tufts-New England Medical Center, Boston, Massachusetts
^¶ Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University of Naples, Naples, Italy.

View larger version (12K): [in a new window]   Figure 1 Survival free from all-cause mortality after surgical myectomy for obstructive hypertrophic cardiomyopathy (n = 289) compared with the age- and gender-matched general U.S. white population. Log-rank, p = 0.2.

View larger version (17K): [in a new window]   Figure 2 Survival free from all-cause mortality in three hypertrophic cardiomyopathy patient subgroups: surgical myectomy (n = 289), nonoperated with obstruction (n = 228), and nonobstructive (n = 820). Overall log-rank, p < 0.001; myectomy versus nonoperated obstructive hypertrophic cardiomyopathy, p < 0.001; myectomy versus nonobstructive hypertrophic cardiomyopathy, p = 0.8.

View larger version (19K): [in a new window]   Figure 3 Survival free from hypertrophic cardiomyopathy-related death among patients in three hypertrophic cardiomyopathy (HCM) subgroups: surgical myectomy (n = 289), nonoperated with obstruction (n = 228), and nonobstructive (n = 820). Overall log-rank, p < 0.001; myectomy versus nonoperated obstructive hypertrophic cardiomyopathy, p < 0.001; myectomy versus nonobstructive hypertrophic cardiomyopathy, p = 0.01.

View larger version (19K): [in a new window]   Figure 4 Survival free from sudden cardiac death among patients in three hypertrophic cardiomyopathy subgroups: surgical myectomy (n = 289), nonoperated with obstruction (n = 228), and nonobstructive (n = 820). Overall log-rank, p = 0.003; myectomy versus nonoperated obstructive hypertrophic cardiomyopathy, p = 0.003; myectomy versus nonobstructive hypertrophic cardiomyopathy, p = 0.3.