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Race and Gender Differences in C-Reactive Protein Levels

Amit Khera, MD, MSc^_*,,_*, Darren K. McGuire, MD, MHSc, FACC^_*,, Sabina A. Murphy, MPH, Harold G. Stanek, MS^_*, Sandeep R. Das, MD, MPH^_*,, Wanpen Vongpatanasin, MD, FACC^_*,, Frank H. Wians, Jr, PhD, Scott M. Grundy, MD, PhD^_*,|| and James A. de Lemos, MD, FACC^_*,

^_* Donald W. Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas
Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas
^|| Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas
Brigham and Women’s Hospital, Boston, Massachusetts.

View larger version (14K): [in a new window]   Figure 1 Comparison of C-reactive protein (CRP) levels between white and black subjects, and between men and women. Data are shown as medians (25th and 75th percentiles); p < 0.001 for each comparison.

View larger version (14K): [in a new window]   Figure 2 Comparison of C-reactive protein (CRP) levels between different race and gender groups. Data are shown as medians (25th and 75th percentiles); p < 0.001.

View larger version (13K): [in a new window]   Figure 3 Adjusted odds ratios and 95% confidence intervals for C-reactive protein (CRP) levels >3 mg/l. White men are the referent group. Filled squares = adjusted for sample weights only; filled diamonds = adjusted for age, diabetes, hypercholesterolemia, high-density lipoprotein cholesterol, hypertension, smoking, body mass index, estrogen use, statin use, creatinine, and sample weights.

View larger version (21K): [in a new window]   Figure 4 Relationship between C-reactive protein (CRP) levels and body mass index (BMI) for different race and gender groups (p < 0.001 for association between CRP levels and body mass index categories for each group; p = 0.001 for interaction of body mass index and gender on log CRP levels).