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Inhibition of Cortisol Production With Metyrapone Prevents Mental Stress-Induced Endothelial Dysfunction and Baroreflex Impairment

Andrew J.M. Broadley, MRCP^_*, Ania Korszun, MRCPsych, Eltigani Abdelaal, MRCP, Valentina Moskvina, PhD^||, Christopher J.H. Jones, FRCP^¶, Gerard B. Nash, PhD, Clare Ray, PhD, John Deanfield, FRCP^# and Michael P. Frenneaux, FRCP, FACC^,_*

^_* Heart and Lung Unit, Torbay Hospital, Torquay, United Kingdom
Bart’s and the London Queen Mary College of Medicine and Dentistry, London, United Kingdom
Department of Cardiovascular Medicine, University of Birmingham Medical School, Birmingham, United Kingdom
Department of Physiology, University of Birmingham Medical School, Birmingham, United Kingdom
^|| Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales, United Kingdom
^¶ Department of Cardiology, University of Wales College of Medicine, Cardiff, Wales, United Kingdom
^# Department of Cardiology, Great Ormond Street Hospital for Children, London, United Kingdom

View larger version (31K): [in a new window]   Figure 1 Hemodynamic response to mental stress. (a) Blood pressure response to stress. (b) Heart rate response to stress. bpm = beats per minute.