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Mode of Death in Advanced Heart Failure

The Comparison of Medical, Pacing, and Defibrillation Therapies in Heart Failure (COMPANION) Trial

Peter Carson, MD, FACC^_*,_*, Inder Anand, MD, FACC, Christopher O’Connor, MD, FACC, Brian Jaski, MD, FACC, Jonathan Steinberg, MD, FACC^||, Amy Lwin, RN^¶, JoAnn Lindenfeld, MD, FACC^#, Jalil Ghali, MD, FACC^_**, Jodi H. Barnet, MS, Arthur M. Feldman, MD, PhD, FACC and Michael R. Bristow, MD, PhD, FACC^#

^_* Veterans Affairs Medical Center, Washington, DC
Division of Cardiology, Veterans Affairs Medical Center, Minneapolis, Minnesota
Division of Cardiology, Duke University, Durham, North Carolina
Advanced Heart Failure and Cardiac Transplant Programs, Sharp Memorial Hospital, San Diego, California
^|| Division of Cardiology, St. Luke’s-Roosevelt Hospital, New York, New York
^¶ Clinical Cardiovascular Research, Gaithersburg, Maryland
^# Division of Cardiology, University of Colorado, Denver, Colorado
^_** Louisiana State University Medical Center, Shreveport, Louisiana
University of Wisconsin, Madison, Wisconsin
Jefferson Medical College, Philadelphia, Pennsylvania

View larger version (25K): [in a new window]   Figure 1 (A) Kaplan-Meier estimates of the time to first cardiac death. (B) Kaplan-Meier estimates of the time to first non-cardiac death. CRT = cardiac resynchronization therapy; CRT-D = cardiac resynchronization therapy with defibrillation; OPT = optimal pharmacologic therapy.

View larger version (18K): [in a new window]   Figure 2 Kaplan-Meier estimate of the time to first pump failure death. CI = confidence interval; HR = hazard ratio; other abbreviations as in Figure 1.

View larger version (19K): [in a new window]   Figure 3 Kaplan-Meier estimate of the time to first sudden cardiac death. Abbreviation as in Figure 1.