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The Incremental Benefit of Rate-Adaptive Pacing on Exercise Performance During Cardiac Resynchronization Therapy

Hung-Fat Tse, MD, FACC^_*, Chung-Wah Siu, MBBS^_*, Kathy L.F. Lee, MBBS^_*, Katherine Fan, MBBS, Hon-Wah Chan, MBBS^_*, Man-Oi Tang, MD^_*, Vella Tsang, RN^_*, Stephen W.L. Lee, MBBS, FACC^_* and Chu-Pak Lau, MD, FACC^_*,_*

^_* Cardiology Division, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
Cardiac Medical Unit, Grantham Hospital, Hong Kong, China

View larger version (47K): [in a new window]   Figure 1 Changes in (A) peak exercise heart rate (HR), (B) exercise time, (C) metabolic equivalents, and (D) peak oxygen consumption during DDD-OFF, DDD-ON, and DDDR-ON modes in patients who achieved <85% (all, n = 20), <70% (n = 11), and 70% to 85% (n = 9) of age-predicted HR during exercise using DDD-OFF mode. Data are expressed as mean values ± SEM. *p values determined by analysis of variance with Bonferroni multiple-comparison tests. White bars = DDD-OFF; ruled bars = DDD-ON; black bars = DDDR-ON.

View larger version (16K): [in a new window]   Figure 2 Correlation between percentage changes in heart rate during exercise with (A) exercise time, (B) metabolic equivalents, and (C) peak oxygen consumption.

View larger version (25K): [in a new window]   Figure 3 Individual changes in peak oxygen consumption during DDD-OFF, DDD-ON, and DDDR-ON modes in patients who achieved <70% (n = 11) and 70% to 85% (n = 9) of age-predicted heart rate (HR) during exercise using DDD-OFF mode. *p values determined by analysis of variance with Bonferroni multiple-comparison tests.