The Effects of Plasma Insulin and Glucose on Myocardial Blood Flow in Patients With Type 1 Diabetes Mellitus
Muthayyah Srinivasan, MBBS, MS*,
Pilar Herrero, MS ,
Janet B. McGill, MD ,
Jasper Bennik, MD,
Bastiaan Heere, MD,
Donna Lesniak, RN,
Victor G. Davila-Roman, MD* and
Robert J. Gropler, MD*,,*
* Cardiovascular Division, Department of Medicine, Edward Mallinckrodt Institute of Radiology, St. Louis, Missouri.
Division of Radiological Sciences, Edward Mallinckrodt Institute of Radiology, St. Louis, Missouri.
Division of Endocrinology and Metabolism, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
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Figure 1 Plasma insulin levels under baseline metabolic conditions and during hyperinsulinemic-euglycemic (HE) and hyperinsulinemic-hyperglycemic clamp (HH).
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Figure 2 Plasma glucose levels under baseline metabolic conditions and during hyperinsulinemic-euglycemic (HE) and hyperinsulinemic-hyperglycemic clamp (HH).
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Figure 3 Myocardial blood flow (MBF) under baseline metabolic conditions and during hyperinsulinemic-euglycemic (HE) and hyperinsulinemic-hyperglycemic clamp (HH). AD = adenosine infusion.
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Figure 4 Myocardial perfusion reserve (MPR) under baseline metabolic conditions and during hyperinsulinemic-euglycemic (HE) and hyperinsulinemic-hyperglycemic clamp (HH).
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