Left Ventricular Non-Compaction
Insights From Cardiovascular Magnetic Resonance Imaging
Steffen E. Petersen, MD*, ,
Joseph B. Selvanayagam, MBBS, FRACP*,,
Frank Wiesmann, MD*,,
Matthew D. Robson, PhD*,,
Jane M. Francis, DCRR, DNM*,,
Robert H. Anderson, MD, FRCPath ,
Hugh Watkins, MD, PhD, FRCP and
Stefan Neubauer, MD, FRCP*,,*
* University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom
Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Cardiac Unit, Institute of Child Health, University College London, London, United Kingdom
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Figure 1 Distribution of non-compaction. The bars represent the percentage of subjects in each group with non-compaction in given segments. The pattern of distribution of non-compaction does not separate the groups.
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Figure 2 Ratio of the end-diastolic thickness of the non-compacted and compacted layers of the myocardium (NC/C ratio). Data are presented as means (squares) and 95% confidence interval (whiskers). **p < 0.01. DCM = dilated cardiomyopathy; HCM = hypertrophic cardiomyopathy; LVNC = left ventricular non-compaction.
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Figure 3 The autosomal dominant pattern of inheritance in a family with pathological left ventricular non-compaction. Diastolic horizontal long-axis views of parents (I:1 father and I:2 mother) and children (II:1, II.2) show variable degrees of non-compaction (black dotted arrows) in I:1 (Patient #3; Table1), II:1 (Patient #2; Table 1), and II:2 (Patient #1; Table 1). Patient II:1 likely illustrates partial expression of pathological non-compaction, because her ratio of end-diastolic thicknesses is <2.3 (1.1).
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