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Positron Emission Tomography-Measured Abnormal Responses of Myocardial Blood Flow to Sympathetic Stimulation Are Associated With the Risk of Developing Cardiovascular Events

Thomas H. Schindler, MD^_*,,_*, Egbert U. Nitzsche, MD, Heinrich R. Schelbert, MD, PhD^_*, Manfred Olschewski, MSc, James Sayre, PhD^_*, Michael Mix, MSc, PhD, Ingo Brink, MD, Xiao-Li Zhang, MD, PhD^_*, Michael Kreissl, MD^_*, Nobuhisa Magosaki, MD, Hanjoerg Just, MD and Ulrich Solzbach, MD

^_* Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California
Division of Cardiology and Nuclear Medicine, and Department for Medical Statistics, University Freiburg, Freiburg, Germany
University of Basel, School of Medicine, Division of Nuclear Medicine, Kantonsspital Aarau, Aarau, Switzerland.

View larger version (19K): [in a new window]   Figure 1 Kaplan-Meier analysis demonstrating the proportion of patients without cardiovascular events during long-term follow-up in patients with normal (group 1), impaired (group 2), and decreased (group 3) myocardial blood flow to cold pressor test.

View larger version (18K): [in a new window]   Figure 2 Patients with at least one cardiovascular event, n (%). Open bar = group 1; striped bar = group 2; solid bar = group 3.

View larger version (18K): [in a new window]   Figure 3 Kaplan-Meier analysis demonstrating the proportion of patients without cardiac events during long-term follow-up in patients with change in myocardial blood flow (MBF) 28% and with MBF <28% to cold pressor test.