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J Am Coll Cardiol, 2005; 45:1494-1504, doi:10.1016/j.jacc.2005.01.036
© 2005 by the American College of Cardiology Foundation
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Ethnic Differences in the Prognostic Value of Stress Technetium-99m Tetrofosmin Gated Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging

Leslee J. Shaw, PhD*,*, Robert C. Hendel, MD{dagger}, Manuel Cerquiera, MD{ddagger}, Jennifer H. Mieres, MD§, Naomi Alazraki, MD||, Elizabeth Krawczynska, MD||, Salvador Borges-Neto, MD, Jamshid Maddahi, MD# and C. Noel Bairey Merz, MD*

* Cedars-Sinai Medical Center, Los Angeles, California
{dagger} Midwest Heart Specialists, Fox River Grove, Illinois
{ddagger} Cleveland Clinic Foundation, Cleveland, Ohio
§ North Shore University, Long Island Jewish Health System, Long Island, New York
|| Emory University, Atlanta VA Medical Center, Atlanta, Georgia
Duke University, Durham, North Carolina
# UCLA Medical Center, Los Angeles, California.



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Figure 1 Frequency of low risk, mildly abnormal, moderately abnormal, and severely abnormal summed stress scores in African American, Hispanic, and Caucasian non-Hispanic patients. Black bars = severe; hatched bars = moderate; dotted bars = mild; white bars = low. p < 0.0001.

 


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Figure 2 Estimated annual death rates by summed stress score risk group in African-American, Hispanic, and Caucasian non-Hispanic patients. All-cause death: chi-square = 33, p < 0.0001; cardiovascular death: chi-square = 127, p < 0.0001; ischemic heart disease death: chi-square = 109, p < 0.0001. CV= cardiovascular; IHD = ischemic heart disease. *No ischemic heart disease deaths reported.

 


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Figure 3 (A) Survival free from cardiovascular death or myocardial infarction in African-American and Hispanic patients. Model chi-square = 192; p < 0.0001. *n = available sample every 0.5 years of follow-up for low, mild, moderate, and severely abnormal scans. (B) Survival free from cardiovascular death or myocardial infarction in Caucasian non-Hispanic patients. Model chi-square = 192; p < 0.0001. *n = available sample every 0.5 years of follow-up for low, mild, moderate, and severely abnormal scans. Asian patients were not included in this analysis because of small sample scans.

 


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Figure 4 Annualized risk-adjusted cardiovascular death or myocardial infarction rate by post-stress left ventricular ejection fraction for African-American, Hispanic, and Caucasian non-Hispanic patients. Line of best fit was a cubic spline fit with 95% confidence intervals.

 


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Figure 5 Risk-adjusted relative risk of cardiac death or myocardial infarction (MI) by summed stress score risk in African-American and Hispanic patients versus Caucasian non-Hispanic patients undergoing Tc-99m myoview single-photon emission computed tomographic imaging. CI = confidence interval.

 


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Figure 6 Risk-adjusted relative risk of cardiac death or myocardial infarction (MI) by summed stress score risk in African-American and Hispanic patients versus Caucasian non-Hispanic patients undergoing adenosine/dipyridamole Tc-99m myoview single-photon emission computed tomographic imaging. CI = confidence interval.

 




 
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