Impaired Progenitor Cell Activity in Age-Related Endothelial Dysfunction
Christian Heiss, MD,
Stefanie Keymel, MS,
Ulrike Niesler, MS,
Jutta Ziemann, BS,
Malte Kelm, MD and
Christoph Kalka, MD*
Department of Cardiology, Pneumology, and Vascular Medicine, Heinrich-Heine-University, Düsseldorf, Germany
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Figure 1 Endothelial dysfunction in old subjects. Whereas (A) flow-mediated dilation (FMD) was significantly impaired in old subjects (n = 20, solid columns), (B) dilation after 400 µg of sublingual glycerol-trinitrate (GTN) was not (n = 20, open columns). (C) A decreased FMD/GTN ratio in the elder group implies specific endothelial dysfunction. Columns are mean ± SE.
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Figure 2 Concentrations of endothelial progenitor cells in old and young subjects. Neither the concentration of (A) KDR/CD133+ or (B) KDR/CD34+ cells was significantly different between old (n = 20, open columns) and young subjects (n = 20, solid columns). Columns represent mean values, error bars are the standard error; p < 0.05.
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Figure 3 The endothelial progenitor cell (EPC) function in old and young individuals. (A) EPC survival, (B) proliferation, and (C) migration are reduced in old (n = 20, open columns) as compared with young study subjects (n = 20, solid columns). Columns represent mean values, error bars are the standard error.
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Figure 4 Correlations of endothelial function and endothelial progenitor cell (EPC) function. Flow-mediated dilation (FMD) correlated with (A) EPC proliferation (r = 0.49, p < 0.05) and (B) migration (r = 0.52, p < 0.01). Open circles = old subjects; solid circles = young subjects.
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