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The Relation of Dosing to Clopidogrel Responsiveness and the Incidence of High Post-Treatment Platelet Aggregation in Patients Undergoing Coronary Stenting

Sinai Center for Thrombosis Research, Baltimore, Maryland

View larger version (32K): [in a new window]   Figure 1 (A) Distribution of post-treatment platelet aggregation as measured by 5 µM adenosine diphosphate (ADP)-induced aggregation. Distribution is shifted leftward for the 600-mg group, indicating lower reactivity to ADP. (B) Distribution of post-treatment platelet aggregation as measured by 20 µM ADP-induced aggregation. Distribution is shifted leftward for the 600-mg group, indicating lower reactivity to ADP.

View larger version (32K): [in a new window]   Figure 2 (A) Distribution of the absolute change in 5 µM adenosine diphosphate (ADP)-induced aggregation (A). All of the patients under the double-headed arrow meet the definition for nonresponsiveness (NR). The distribution is shifted rightward in the 600-mg group, indicating greater inhibition (responsiveness to clopidogrel). (B) Distribution of the absolute change in 20 µM ADP-induced aggregation (A). All of the patients under the double-headed arrow meet the definition for NR. The distribution is shifted rightward in the 600-mg group, indicating greater inhibition (responsiveness to clopidogrel).

View larger version (18K): [in a new window]   Figure 3 Relation of post-treatment platelet aggregation (Post-PA) to nonresponsiveness in 300- and 600-mg groups as measured by 5 µM adenosine-diphosphate-induced aggregation.

View larger version (18K): [in a new window]   Figure 4 Relation of post-treatment platelet aggregation (Post-PA) to nonresponsiveness in 300- and 600-mg groups as measured by 20 µM adenosine-diphosphate-induced aggregation.