Radiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract improves left ventricular dilation and clinical status in patients without structural heart disease
Masao Takemoto, MD*,
Hitoshi Yoshimura, MD,
Yurika Ohba, MD,
Yasuharu Matsumoto, MD,
Umpei Yamamoto, MD,
Masahiro Mohri, MD,
Hideo Yamamoto, MD and
Hideki Origuchi, MD
Internal Medicine, Kyushu Kosei-Nenkin Hospital, Kitakyushu, Japan.
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Figure 1 Scatter plots showing the relationship between the left ventricular end-diastolic internal dimension (LVDd) and frequency of premature ventricular complex (%PVC) (n = 40).
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Figure 2 The analysis of left ventricular ejection fraction (LVEF) (A), left ventricular end-diastolic internal dimension (LVDd) (B), left ventricular end-systolic internal dimension (LVDs) (C), degree of mitral regurgitation (MR) (D), and right ventricular internal dimension (RVD) (E) by echocardiogram, and cardiothoracic ratio (CTR) (F) by chest radiography before (dotted bars) and 1 day (gray bars) or 6 to 12 months after (solid bars) radiofrequency catheter ablation (RFA). Before RFA and one day after RFA, a subgroup of patients with frequent (>20%) premature ventricular complexes (PVC) demonstrated significantly reduced LVEF, enlarged LVDd and LVDs, and increased MR and CTR as compared to the subgroup with rare (<20%) PVC. However, all of these abnormalities seen in the upper group before RFA were completely reversed 6 to 12 months after RFA. There was no evidence of right ventricular abnormalities in any patient. *p < 0.05 versus before and one day after RFA in each group;  p < 0.05 versus the lower and middle groups in each period. Values are mean ± SD.
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Figure 3 The analysis of New York Heart Association (NYHA) functional class before (dotted bars) and 6 to 12 months after (solid bars) radiofrequency catheter ablation (RFA). Before ablation, NYHA functional class was significantly worse in accordance with frequency of premature ventricular complex (%PVC); RFA significantly improved NYHA functional class in each group compared with before intervention. **p < 0.01, *p < 0.05 versus before RFA in each group. p < 0.05 versus the lower and middle groups in each period. Values are mean ± SD.
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