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J Am Coll Cardiol, 2005; 45:1206-1212, doi:10.1016/j.jacc.2005.01.005
© 2005 by the American College of Cardiology Foundation
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Surrogates, substudies, and real clinical end points in trials of drug-eluting stents*

Dean J. Kereiakes, MD, FACC{dagger},*,1, Richard E. Kuntz, MD, MSc{ddagger}, Laura Mauri, MD, MSc{ddagger} and Mitchell W. Krucoff, MD, FACC2,§

{dagger} The Lindner Center for Research & Education at The Christ Hospital and The Ohio Heart Health Center, Cincinnati, Ohio
{ddagger} Divisions of Cardiology and Clinical Biometrics, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
§ Duke Clinical Research Institute, Duke University, Durham, North Carolina.



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Figure 1 Relative risk for major adverse cardiovascular events (MACE) up to nine months in randomized trials of the TAXUS paclitaxel-eluting stent; MACE is composite occurrence of cardiovascular death, myocardial infarction, or target vessel revascularization (see text). MR = moderate release; SR = slow release.

 





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