Polymer-based paclitaxel-eluting stents reduce in-stent neointimal tissue proliferation
A serial volumetric intravascular ultrasound analysis from the TAXUS-IV trial
Neil J. Weissman, MD, FACC*,*,
Joerg Koglin, MD
,
David A. Cox, MD, FACC
,
James Hermiller, MD, FACC
,
Charles OShaughnessy, MD, FACC||,
James Tift Mann, MD, FACC¶,
Mark Turco, MD, FACC#,
Ronald Caputo, MD, FACC**,
Patrick Bergin, MD, FACC
,
Joel Greenberg, MD, FACC
,
Michael Kutcher, MD, FACC
,
S. Chiu Wong, MD, FACC||||,
Warren Strickland, MD, FACC¶¶,
Michael Mooney, MD, FACC##,
Mary E. Russell, MD, FACC
,
Stephen G. Ellis, MD, FACC*** and
Gregg W. Stone, MD, FACC

,

* Washington Hospital Center, Washington, DC
Boston Scientific Corp., Natick, Massachusetts
Mid Carolina Cardiology, Charlotte, North Carolina
St. Vincents Hospital, Indianapolis, Indiana
|| Elyria Memorial Hospital, Elyria, Ohio
¶ WakeMed, Raleigh, North Carolina
# Washington Adventist Hospital, Tacoma Park, Maryland
** St. Josephs Hospital, Syracuse, New York

Sacred Heart Medical Center, Eugene, Oregon

Florida Hospital, Orlando, Florida

Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina
|||| New York Presbyterian Hospital, New York, New York
¶¶ Huntsville Hospital, Huntsville, Alabama
## Abbott Northwestern Hospital, Minneapolis, Minnesota
*** Cleveland Clinic Foundation, Cleveland Ohio


College of Physicians and Surgeons, Columbia University, New York, New York


Cardiovascular Research Foundation, New York, New York.

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Figure 1 Change in vessel (A), plaque (B), and lumen (C) area from post-procedure to nine months for TAXUS and the bare-metal control groups in the stented segments and the edges. Measurements were made every 1 mm, and baseline and follow-up measurements are aligned to the stent edges. Results are reported for the proximal and distal 7 mm of each stent to correct for differences in stent length. Within the stent, neointima growth is displayed in panel B rather than plaque outside the stent. *p < 0.05; +p < 0.01; #p < 0.001.
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Figure 2 Percentage of patients with incomplete apposition after procedure and at nine-month follow-up. Solid bars = control group; open bars = TAXUS group.
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Copyright © 2005 by the American College of Cardiology Foundation.