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J Am Coll Cardiol, 2005; 45:1201-1205, doi:10.1016/j.jacc.2004.10.078
© 2005 by the American College of Cardiology Foundation
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Polymer-based paclitaxel-eluting stents reduce in-stent neointimal tissue proliferation

A serial volumetric intravascular ultrasound analysis from the TAXUS-IV trial

Neil J. Weissman, MD, FACC*,*, Joerg Koglin, MD{dagger}, David A. Cox, MD, FACC{ddagger}, James Hermiller, MD, FACC§, Charles O’Shaughnessy, MD, FACC||, James Tift Mann, MD, FACC, Mark Turco, MD, FACC#, Ronald Caputo, MD, FACC**, Patrick Bergin, MD, FACC{dagger}{dagger}, Joel Greenberg, MD, FACC{ddagger}{ddagger}, Michael Kutcher, MD, FACC§§, S. Chiu Wong, MD, FACC||||, Warren Strickland, MD, FACC¶¶, Michael Mooney, MD, FACC##, Mary E. Russell, MD, FACC{dagger}, Stephen G. Ellis, MD, FACC*** and Gregg W. Stone, MD, FACC{dagger}{dagger}{dagger},{ddagger}{ddagger}{ddagger}

* Washington Hospital Center, Washington, DC
{dagger} Boston Scientific Corp., Natick, Massachusetts
{ddagger} Mid Carolina Cardiology, Charlotte, North Carolina
§ St. Vincent’s Hospital, Indianapolis, Indiana
|| Elyria Memorial Hospital, Elyria, Ohio
WakeMed, Raleigh, North Carolina
# Washington Adventist Hospital, Tacoma Park, Maryland
** St. Joseph’s Hospital, Syracuse, New York
{dagger}{dagger} Sacred Heart Medical Center, Eugene, Oregon
{ddagger}{ddagger} Florida Hospital, Orlando, Florida
§§ Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina
|||| New York Presbyterian Hospital, New York, New York
¶¶ Huntsville Hospital, Huntsville, Alabama
## Abbott Northwestern Hospital, Minneapolis, Minnesota
*** Cleveland Clinic Foundation, Cleveland Ohio
{dagger}{dagger}{dagger} College of Physicians and Surgeons, Columbia University, New York, New York
{ddagger}{ddagger}{ddagger} Cardiovascular Research Foundation, New York, New York.



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Figure 1 Change in vessel (A), plaque (B), and lumen (C) area from post-procedure to nine months for TAXUS and the bare-metal control groups in the stented segments and the edges. Measurements were made every 1 mm, and baseline and follow-up measurements are aligned to the stent edges. Results are reported for the proximal and distal 7 mm of each stent to correct for differences in stent length. Within the stent, neointima growth is displayed in panel B rather than plaque outside the stent. *p < 0.05; +p < 0.01; #p < 0.001.

 


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Figure 2 Percentage of patients with incomplete apposition after procedure and at nine-month follow-up. Solid bars = control group; open bars = TAXUS group.

 





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