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Relationship between angiographic late loss and target lesion revascularization after coronary stent implantation

Analysis from the TAXUS-IV trial

Stephen G. Ellis, MD^_*,_*, Jeffrey J. Popma, MD, John M. Lasala, MD, PhD, Joerg J. Koglin, MD, David A. Cox, MD^||, James Hermiller, MD^¶, Charles O’Shaughnessy, MD^#, James Tift Mann, MD^_**, Mark Turco, MD, Ronald Caputo, MD, Patrick Bergin, MD, Joel Greenberg, MD^|||| and Gregg W. Stone, MD^¶¶,##

^_* Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio
Brigham & Women’s Hospital, Boston, Massachusetts
Division of Cardiology, Washington University, School of Medicine, St. Louis, Missouri
Cardiovascular Clinical Affairs, Boston Scientific, Natick, Massachusetts
^|| Mid Carolina Cardiology, Charlotte, North Carolina
^¶ St. Vincent’s Hospital, Indianapolis, Indiana
^# Elyria Memorial Hospital, Elyria, Ohio
^_** WakeMed, Raleigh, North Carolina
Washington Adventist Hospital, Tacoma Park, Maryland
St. Joseph’s Hospital, Syracuse, New York
Sacred Heart Medical Center, Eugene, Oregon
^|||| Florida Hospital, Orlando, Florida
^¶¶ Columbia University Medical Center, New York, New York
^## Cardiovascular Research Foundation, New York, New York.

View larger version (35K): [in a new window]   Figure 1 Histograms for late loss for the paclitaxel-eluting and control bare-metal EXPRESS stent groups for in-stent (A), analysis segment (B), and maximal regional (C) late loss definitions. Paclitaxel-eluting-treated patients had less, but more heterogeneously distributed, late loss.

View larger version (25K): [in a new window]   Figure 2 Patient count data for those with and without target lesion revascularization (TLR), dividing late loss into 0.2-mm increments: (A) in-stent, (B) analysis segment, (C) maximal regional late loss.

View larger version (14K): [in a new window]   Figure 3 Cumulative frequency distribution curves for (A) in-stent, (B) in-segment, (C) maximal regional late loss for the combined angiographic populations versus target lesion revascularization (TLR). Prob = probability.

View larger version (16K): [in a new window]   Figure 4 Cumulative frequency distribution cares for in-segment late loss versus target lesion revascularization (TLR) for reference vessel size <2.5, 2.5 to 3.0, and >3.0 mm. Prob = probability.