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J Am Coll Cardiol, 2005; 45:1172-1179, doi:10.1016/j.jacc.2004.10.075
© 2005 by the American College of Cardiology Foundation
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Outcomes with the polymer-based paclitaxel-eluting TAXUS stent in patients with diabetes mellitus

The TAXUS-IV trial

James B. Hermiller, MD, FACC*,1, Albert Raizner, MD, FACC{dagger}, Louis Cannon, MD, FACC{ddagger}, Paul A. Gurbel, MD, FACC§, Michael A. Kutcher, MD, FACC||, S. Chiu Wong, MD, FACC, Mary E. Russell, MD#,2, Stephen G. Ellis, MD, FACC**,1, Roxana Mehran, MD, FACC{dagger}{dagger}, Gregg W. Stone, MD, FACC{dagger}{dagger},1,* TAXUS-IV Investigators

* St. Vincent’s Hospital, Indianapolis, Indiana
{dagger} Cardiac Cath Lab Research Center, Houston, Texas
{ddagger} St. Mary’s Medical Center, Saginaw, Michigan
§ Sinai Hospital of Baltimore, Baltimore, Maryland
|| Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina
New York Presbyterian Hospital, New York, New York
# Boston Scientific Corp., Natick, Massachusetts
** Cleveland Clinic Foundation, Cleveland, Ohio
{dagger}{dagger} Columbia University Medical Center and the Cardiovascular Research Foundation, New York, New York



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Figure 1 One-year clinical outcomes among patients randomized to the paclitaxel-eluting TAXUS stent versus a control EXPRESS stent, stratified by diabetic status and treatment type. (Upper left graph) Composite major adverse cardiac events. (Upper right graph) Target vessel failure. (Lower left graph) Target vessel revascularization. (Lower right graph) Target lesion revascularization.

 


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Figure 2 Nine-month rates of binary restenosis among patients randomized to the paclitaxel-eluting TAXUS stent versus a control EXPRESS stent, stratified by diabetic status and treatment type. (Left) In-stent restenosis. (Right) Analysis segment restenosis. Black bars = control; open bars = TAXUS.

 





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