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Echocardiographic predictors of morbidity and mortality in patients with advanced heart failure

The Beta-blocker Evaluation of Survival Trial (BEST)

Paul A. Grayburn, MD^_*,_*, Christopher P. Appleton, MD, Anthony N. DeMaria, MD, Barry Greenberg, MD, Brian Lowes, MD, Jae Oh, MD^||, Jonathan F. Plehn, MD^¶, Peter Rahko, MD^#, Martin St. John Sutton, MD^_**, Eric J. Eichhorn, MD^_* the BEST Trial Echocardiographic Substudy Investigators

^_* Echocardiographic Core Laboratory, Baylor University Medical Center, Dallas, Texas
Mayo Clinic Scottsdale, Scottsdale, Arizona
University of California, San Diego, San Diego, California
University of Colorado, Denver, Colorado
^|| Mayo Clinic Rochester, Rochester, Minnesota
^¶ National Heart, Lung, and Blood Institute, Washington, DC
^# University of Wisconsin, Madison, Wisconsin
^_** University of Pennsylvania, Philadelphia, Pennsylvania

View larger version (12K): [in a new window]   Figure 1 Kaplan-Meier plot showing time to death by left ventricular (LV) end-diastolic volume index. Patients are stratified according to LV end-diastolic volume index 120 ml/m2 versus >120 ml/m2. E = events.

View larger version (18K): [in a new window]   Figure 2 Kaplan-Meier plots showing time to the combined end point of death, heart failure hospitalization, or transplant for patients with a left ventricular end-diastolic volume index (LVEDVI) 120 ml/m2 versus >120 ml/m2 (top panel), a mitral deceleration time (DT) 150 ms versus <150 ms (middle panel), and a mitral regurgitation vena contracta width (VCW) of 0.4 cm versus >0.4 cm (bottom panel). Variables included in the model were LVEDVI, mitral DT, and mitral regurgitation VCW. E = events.