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Community screening for left ventricular systolic dysfunction using plasma and urinary natriuretic peptides

Leong L. Ng, MD^_*,_*, Ian W. Loke, MB^_*, Joan E. Davies, PhD^_*,, Sandeep Geeranavar, BSc^_*, Kamlesh Khunti, MD, Margaret A. Stone, PhD, Derek T. Chin, MB and Iain B. Squire, MD^_*

^_* Department of Cardiovascular Sciences, University of Leicester, United Kingdom
Department of Health Sciences, University of Leicester, United Kingdom
Department of Cardiology, Glenfield Hospital, Leicester, United Kingdom

View larger version (17K): [in a new window]   Figure 1 The receiver-operating characteristic curves for plasma and urinary N-terminal pro-brain natriuretic peptide (N-BNP) and the plasma/urinary N-BNP product in left ventricular systolic dysfunction detection. Solid line = urinary N-BNP; dotted line = urinary x plasma N-BNP; dashed line = plasma N-BNP.

View larger version (32K): [in a new window]   Figure 2 A scatterplot of urinary and plasma N-terminal pro-brain natriuretic peptide (N-BNP) in those subjects with a positive urine test (defined as >10.7 fmol/ml). Normal subjects (open circles) or subjects with left ventricular systolic dysfunction (solid triangles).

View larger version (14K): [in a new window]   Figure 3 The receiver-operating characteristic curves for plasma and urinary N-terminal pro-brain natriuretic peptide (N-BNP) and the plasma/urinary N-BNP product in left ventricular systolic dysfunction detection within a high-risk group (age >65 years, hypertension, ischemic heart disease).

View larger version (19K): [in a new window]   Figure 4 Stability of urinary N-terminal pro-brain natriuretic peptide (N-BNP) when stored at room temperature for up to 72 h.