Long-term survival and functional results after aortic valve replacement in asymptomatic patients with chronic severe aortic regurgitation and left ventricular dysfunction
Roldano Scognamiglio, MD*,
Christian Negut, MD,
Monica Palisi, MD,
Giuseppe Fasoli, MD and
Sergio Dalla-Volta, MD
Division of Cardiology, Department of Clinical and Experimental Medicine, University of Padua Medical School, Padua, Italy
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Figure 1 Survival of patients with chronic severe aortic regurgitation after surgery according to study group and compared with expected survival (solid triangles = group A patients; open triangles = general population matched with group A; solid squares = group B patients; open squares = general population matched with group B). Survival at five years is similar in the two study groups and is not different from expected survival in group A. Ten-year survival of group A does not differ from expected and is significantly higher than that in group B (p < 0.001). Ten-year survival of group B is worse than expected.
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Figure 2 Changes in left ventricular ejection fraction (LVEF) after surgical correction of chronic severe aortic regurgitation (solid triangles = group A patients; open triangles = group B patients). Group A and B patients have similar preoperative values (Pre-op). The LVEF is higher in group A patients after the procedure (Post-op) (p < 0.001) and at five-year (p < 0.001) and 10-year follow-up (p < 0.001).
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Figure 3 Changes in left ventricular end-diastolic volume index (LVEDVI) after aortic valve replacement in study groups of patients with chronic severe aortic regurgitation (solid squares = group A patients; solid triangles = group B patients). Group A and B patients have similar preoperative (Pre-op) values. After valve replacement, LVEDVI decreases significantly both in group A (p < 0.001) and group B (p < 0.001). After surgery (Post-op), significantly higher values of LVEDVI are present in group B (p < 0.001) and are still present at five-year (p < 0.001) and 10-year follow-up study (p < 0.001).
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