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Long-term survival and functional results after aortic valve replacement in asymptomatic patients with chronic severe aortic regurgitation and left ventricular dysfunction

Division of Cardiology, Department of Clinical and Experimental Medicine, University of Padua Medical School, Padua, Italy

View larger version (18K): [in a new window]   Figure 1 Survival of patients with chronic severe aortic regurgitation after surgery according to study group and compared with expected survival (solid triangles = group A patients; open triangles = general population matched with group A; solid squares = group B patients; open squares = general population matched with group B). Survival at five years is similar in the two study groups and is not different from expected survival in group A. Ten-year survival of group A does not differ from expected and is significantly higher than that in group B (p < 0.001). Ten-year survival of group B is worse than expected.

View larger version (12K): [in a new window]   Figure 2 Changes in left ventricular ejection fraction (LVEF) after surgical correction of chronic severe aortic regurgitation (solid triangles = group A patients; open triangles = group B patients). Group A and B patients have similar preoperative values (Pre-op). The LVEF is higher in group A patients after the procedure (Post-op) (p < 0.001) and at five-year (p < 0.001) and 10-year follow-up (p < 0.001).

View larger version (15K): [in a new window]   Figure 3 Changes in left ventricular end-diastolic volume index (LVEDVI) after aortic valve replacement in study groups of patients with chronic severe aortic regurgitation (solid squares = group A patients; solid triangles = group B patients). Group A and B patients have similar preoperative (Pre-op) values. After valve replacement, LVEDVI decreases significantly both in group A (p < 0.001) and group B (p < 0.001). After surgery (Post-op), significantly higher values of LVEDVI are present in group B (p < 0.001) and are still present at five-year (p < 0.001) and 10-year follow-up study (p < 0.001).