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The apolipoprotein CI content of triglyceride-rich lipoproteins independently predicts early atherosclerosis in healthy middle-aged men

Anders Hamsten, MD, PhD^_*, Angela Silveira, PhD^_*, Susanna Boquist, MD, PhD, Rong Tang, MD, M. Gene Bond, PhD, Ulf de Faire, MD, PhD and Johan Björkegren, MD, PhD^_*,_*

^* Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Institutet, Stockholm, Sweden
Cardiology Unit, Karolinska Hospital, Stockholm, Sweden
Division of Ultrasound, Department of Neurobiology and Anatomy, Wake Forest University, Winston-Salem, North Carolina
Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

View larger version (15K): [in a new window]   Figure 1 The plasma triglyceride concentrations before and after a standardized mixed meal containing 1,000 kcal (60% of energy from fat) in 72 healthy 50-year-old men. Pearson correlation coefficient (r) to intima-media thickness and *p < 0.05; p < 0.01.

View larger version (20K): [in a new window]   Figure 2 Regression plot of the log-normalized (ln) cholesterol and apolipoprotein (apo) CI concentrations of the Svedberg flotation 20 to 400 fraction. *p < 0.0001. VLDL = very-low-density lipoprotein.