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Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease

Paul N. Hopkins, MD, MSPH^_*,_*, Lily L. Wu, PhD^_*,, Steven C. Hunt, PhD^_* and Eliot A. Brinton, MD^_*

^_* Cardiovascular Genetics, Department of Internal Medicine, Cardiology Division, University of Utah School of Medicine, Associated Regional and University Pathologists, Salt Lake City, Utah
Department of Pathology, University of Utah School of Medicine, Associated Regional and University Pathologists, Salt Lake City, Utah

View larger version (49K): [in a new window]   Figure 1 Odds ratios for premature coronary artery disease in mutually exclusive plasma triglyceride and high-density lipoprotein (HDL) categories. Confidence intervals and p values are given in Table 3.

View larger version (63K): [in a new window]   Figure 2 Prevalence of metabolic syndrome and contributing factors by plasma triglyceride concentration in cases (A) and control subjects (B). The legend shows triglyceride strata (mg/dl). Cut points for factors of the metabolic syndrome are as defined by ATP-III except body mass index (BMI) which for this study was defined as BMI 30 kg/m2. All trends were significant with p < 0.0001 except for the high blood pressure (BP) in cases for which the p value for trend was 0.002. Patients with type III hyperlipidemia were excluded. HDL = high-density lipoprotein.

View larger version (51K): [in a new window]   Figure 3 Odds ratios of premature coronary artery disease in triglyceride (TG)/high-density lipoprotein (HDL) categories and by hypertension. Odds ratios for normal blood pressure (NBP), high HDL, high TG and low HDL, low TG categories were significant at p = 0.006 and 0.0010 respectively. All others are significant at p <0.0001. HBP = high blood pressure.

View larger version (39K): [in a new window]   Figure 4 Summary of coronary artery disease risk (odds ratios and 95% confidence intervals) associated with commonly used cut points. Risks were estimated simultaneously in a multiple logistic regression model adjusting for age, gender, hypertension, diabetes, serum albumin, bilirubin, creatinine, and low-density lipoprotein cholesterol. HDL = high-density lipoprotein; TG = triglycerides.