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Prior exercise training improves the outcome of acute myocardial infarction in the rat

Heart structure, function, and gene expression

Sarit Freimann, PhD^*,, Mickey Scheinowitz, PhD^,, Daniel Yekutieli, PhD, Micha S. Feinberg, MD^||, Michael Eldar, MD^|| and Gania Kessler-Icekson, PhD^*,*

^* Felsenstein Medical Research Center, Tel-Aviv University, Tel-Aviv, Israel
Neufeld Cardiac Research Institute, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Department of Biomedical Engineering, Tel-Aviv University, Tel-Aviv, Israel
Department of Statistics and Operation Research, Tel-Aviv University, Tel-Aviv, Israel
^|| The Heart Institute, Sheba Medical Center, Tel-Aviv University, Tel-Aviv, Israel

View larger version (72K): [in a new window]   Figure 1 Measurements of scar size. (A) Representative transversal sections stained with Masson trichrome; bars = scar borders. (B) Relative scar area expressed as percent of left ventricular (LV) cross-sectional area. Values expressed as mean ± SD. *p = 0.00007 vs. SedMI; SedMI, n = 15; ExMI, n = 14. ExMI = exercised-infarcted; MI = myocardial infarction; SedMI = sedentary-infarcted.

View larger version (13K): [in a new window]   Figure 2 Measurements of left ventricular function. (A) Left ventricular end-systolic diameter (LVESD) and left ventricular end-diastolic diameter (LVEDD) were measured by echocardiography four weeks after myocardial infarction. (B) Left ventricular shortening fraction (SF [percent]) in the same hearts. Values expressed as mean ± SD. *p = 0.003; #p = 0.001 vs. SedMI. In panel A, solid bar = SedMI and open bar = ExMI. ExMI = exercised-infarcted (n = 8); SedMI = sedentary-infarcted (n = 4).

View larger version (20K): [in a new window]   Figure 3 Relative gene expression deduced from cDNA arrays. Scatter plots comparing (A) exercised-infarcted (ExMI) with sedentary-infarcted (SedMI). (B) Exercised-infarcted with Ex. (C) Sedentary-infarcted with Sed. The score for each gene is expressed as percent of the global expression. The middle diagonal marks the line of identity and the upper and lower diagonals outline the range of 1.5-fold change. The numbers denote the positions of atrial natriuretic peptide (1), cytochrome c-oxidase (COX) subunit 6A (2), and COX subunit 8h (3).

View larger version (16K): [in a new window]   Figure 4 Expression of selected genes. RNA of individual hearts was analyzed for (A) atrial natriuretic peptide (by Northern blot hybridization); (B) energy metabolism-related genes (by quantitative reverse transcription polymerase chain reaction). Values expressed as mean ± SD; *p 0.03 vs. sedentary-infarcted (SedMI); n = 5 in each SedMI and exercised-infarcted (ExMI) group. Solid bar = SedMI; open bar = ExMI. AU = arbitrary units; COX 6A and COX 8h = subunits of cytochrome C-oxidase; H-FABP = heart fatty acid binding protein.