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Better outcome after pediatric defibrillation dosage than adult dosage in a swine model of pediatric ventricular fibrillation

Robert A. Berg, MD^*,*, Ricardo A. Samson, MD^*,, Marc D. Berg, MD^*,, Fred W. Chapman, PhD, Ronald W. Hilwig, PhD, DVM, Isabelle Banville, PhD, Robert G. Walker, BS, Richard C. Nova, MS, PE, Nathan Anavy, BS and Karl B. Kern, MD

^* University of Arizona Steele Memorial Children's Research Center, Tucson, Arizona
Sarver Heart Center, Tucson, Arizona
Medtronic Emergency Response Systems, Inc., Redmond, Washington

View larger version (20K): [in a new window]   Figure 1 Resuscitation outcomes of piglets receiving pediatric (black bars) versus adult (white bars) defibrillation shocks. ROSC = return of spontaneous circulation; VF = ventricular fibrillation; neuro = neurologic outcome; cTnT = cardiac troponin T, negative cTnT refers to undetectable cTnT 4 h postresuscitation. *p < 0.005; p = 0.01.

View larger version (17K): [in a new window]   Figure 2 Changes in left-ventricular ejection fraction (EF) from pre-ventricular fibrillation baseline (BL) to 1 and 4 h postresuscitation. Mean ± SEM.*p < 0.05, p < 0.01.