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Angiotensin II receptor blockade reduces new-onset atrial fibrillation and subsequent stroke compared to atenolol

The Losartan Intervention For End point reduction in hypertension (LIFE) study

Kristian Wachtell, MD, PhD^*,,*, Mika Lehto, MD, Eva Gerdts, MD, PhD, Michael H. Olsen, MD, PhD^*, Björn Hornestam, MD^||, Björn Dahlöf, MD, PhD, FACC^||, Hans Ibsen, MD^*, Stevo Julius, MD, FACC^¶, Sverre E. Kjeldsen, MD, PhD, FACC^¶,#, Lars H. Lindholm, MD, FACC^**, Markku S. Nieminen, MD, FACC and Richard B. Devereux, MD, FACC

^* Department of Medicine, Glostrup University Hospital, Glostrup, Denmark
Division of Cardiology, Weill Medical College of Cornell University, New York, New York
Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
Department of Cardiology, Haukeland University Hospital, Bergen, Norway
^|| Department of Medicine, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden
^¶ Department of Medicine, University of Michigan, Ann Arbor, Michigan
^# Department of Medicine, Ullevål University Hospital, Oslo, Norway
^** Department of Preventive Medicine, Umeå University Hospital, Umeå, Sweden

View larger version (34K): [in a new window]   Figure 1 Trial profile.

View larger version (25K): [in a new window]   Figure 2 Kaplan-Meier curves illustrating new-onset electrocardiogram-verified atrial fibrillation during follow-up. CI = confidence interval; HR = hazard ratio.