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Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers

Department of Internal Medicine III, Kurume University School of Medicine, Kurume, Japan

View larger version (37K): [in a new window]   Figure 1 Time course of platelet aggregations in subjects who quit smoking (group A, open bars) and subjects who resumed smoking (group B, solid bars). Note that platelet aggregations were time-dependently decreased after smoking cessation; however, in the subjects who resumed smoking, platelet aggregations returned to the baseline values by resmoking. *p < 0.01 vs. day 0 in group A; p < 0.05 vs. day 0 in group B; p < 0.05 vs. day 14 in group B. ADP = adenosine diphosphate.

View larger version (15K): [in a new window]   Figure 2 Time course of platelet-derived nitric oxide (PDNO) in subjects who quit smoking (group A, open bars) and subjects who resumed smoking (group B, solid bars). Note that PDNO was time-dependently increased after smoking cessation; however, in the subjects who resumed smoking, PDNO returned to the baseline values by resmoking. *p < 0.01 vs. day 0 in group A; p < 0.05 vs. day 0 in group B; p < 0.05 vs. day 14 in group B.

View larger version (17K): [in a new window]   Figure 3 Time course of intraplatelet reduced form of glutathione (GSH)/oxidized form of glutathione (GSSG) in subjects who quit smoking (group A, open bars) and subjects who resumed smoking (group B, solid bars). Note that intraplatelet GSH/GSSG was time-dependently increased after smoking cessation; however, in the subjects who resumed smoking, intraplatelet GSH/GSSG returned to the baseline values by resmoking. *p < 0.01 vs. day 0 in group A; p < 0.05 vs. day 0 in group B; p < 0.05 vs. day 14 in group B.

View larger version (13K): [in a new window]   Figure 4 Time course of intraplatelet nitrotyrosine in subjects who quit smoking (group A, open bars) and subjects who resumed smoking (group B, solid bars). Note that intraplatelet nitrotyrosine was time-dependently decreased after smoking cessation; however, in the subjects who resumed smoking, intraplatelet nitrotyrosine returned to the baseline values by resmoking. *p < 0.01 vs. day 0 in group A; p < 0.05 vs. day 0 in group B; p < 0.05 vs. day 14 in group B.

View larger version (18K): [in a new window]   Figure 5 Time course of markers of systemic oxidative stress ([A]: urinary 8-OHdG; [B]: urinary 8-iso-PGF2) in subjects who quit smoking (group A, open bars) and subjects who resumed smoking (group B, solid bars). Note that those markers were time-dependently decreased after smoking cessation; however, in the subjects who resumed smoking, those markers returned to the baseline values by resmoking. *p < 0.01 vs. day 0 in group A; p < 0.05 vs. day 0 in group B; p < 0.05 vs. day 14 in group B. 8-iso-PGF2 = 8-iso-prostaglandin F2; 8-OHdG = 8-hydroxy-2'-deoxyguanosine.