Quantitative relation between hemodynamic changes during intravenous adenosine infusion and the magnitude of coronary hyperemia
Implications for myocardial perfusion imaging
Rakesh K. Mishra, MD, FACC*,
Sharmila Dorbala, MD, FACC*,
Giridhar Logsetty, MD*,
Alita Hassan, MPH ,
Therese Heinonen, PhD ,
Heinrich R. Schelbert, MD, FACC ,
Marcelo F. Di Carli, MD, FACC*,* RAMPART Investigators
* Division of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts
Pfizer Global Research and Development, Ann Arbor, Michigan
Montreal Heart Institute, Montreal, Canada
UCLA School of Medicine, Los Angeles, California
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Figure 1 Scatter plots showing the relationships between hyperemic myocardial blood flow and the delta change in heart rate (left panel), and the delta change in mean arterial pressure (right panel) during adenosine infusion.
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Figure 2 Bar charts depicting the differences in mean hyperemic myocardial blood flow (MBF) (left panel), coronary vascular resistance (middle panel), and coronary flow reserve (right panel) between the upper (UP), intermediate (INT), and lower (LOW) tertiles of delta heart rate during adenosine infusion. *p = 0.046 vs. LOW.
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Figure 3 Bar charts depicting the differences in mean hyperemic myocardial blood flow (left panel), coronary vascular resistance (middle panel), and coronary flow reserve (right panel) between the upper (UP), intermediate (INT), and lower (LOW) tertiles of delta mean arterial pressure during adenosine infusion. *p = 0.02 vs. LOW; **p < 0.001 vs. LOW.
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