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Primary angioplasty is cost-minimizing compared with pre-hospital thrombolysis for patients within 60 min of a percutaneous coronary intervention center

The Comparison of Angioplasty and Pre-hospital Thrombolysis in Acute Myocardial Infarction (CAPTIM) cost-efficacy sub-study

Jacques Machecourt, MD^*,*, Eric Bonnefoy, MD, Gérald Vanzetto, MD^*, Pascal Motreff, MD, Stéphanie Marlière, MD^*, Alain Leizorovicz, MD, PhD, Benoit Allenet, PhD^||, Jean Michel Lacroute, MD^¶, Jean Cassagnes, MD and Paul Touboul, MD

^* Coronary Care Unit
^|| Pharmacy Department, CHU Grenoble, Grenoble, France
Coronary Care Unit, Hopital Louis Pradel, Lyon, France
Coronary Care Unit, Centre Hospitalo Universitaire Clermont Ferrand, Clermont Ferrand, France
Clinical Pharmacology Unit, Laennec University, Lyon, France
^¶ Service d'Aide Médicale Urgente (SAMU) 38, Grenoble, France

View larger version (33K): [in a new window]   Figure 1 Subgroup analysis of difference of cost between pre-hospital thrombolysis (PHT) and primary coronary intervention (PCI), according to the baseline presentation, the presence of an immediate or emergent revascularization, the occurrence of a major cardiac event (composite of death, myocardial infarction [MI], or stroke) or bleeding. White bars = PHT group; black bars = PCI group. For a global risk alpha = 5%, the significance level for each analysis was p < 0.0086. SBP = systolic blood pressure.