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The impact of implantable cardioverter-defibrillator therapy on survival in autosomal-dominant arrhythmogenic right ventricular cardiomyopathy (ARVD5)

Kathy A. Hodgkinson, MSc^*,, Patrick S. Parfrey, MD, FRCPC, FACP^*,*, Anne S. Bassett, MD, FRCPC^,, Christine Kupprion, MD, Jörg Drenckhahn, MD, Mark W. Norman, MD, MRCP, Ludwig Thierfelder, MD, Susan N. Stuckless, MSc^*, Elizabeth L. Dicks, MSc^*, William J. McKenna, MD, FRCP^|| and Sean P. Connors, MD, DPhil, FRCPC^¶

^* Clinical Epidemiology Unit
Discipline of Genetics, Memorial University, Health Sciences Centre, St. John's, Newfoundland, Canada
Clinical Genetics Research Program, Centre for Addiction & Mental Health, University of Toronto, Toronto, Ontario, Canada
Max-Delbrück Centrum fur Molekulare Medizin, Berlin, Germany
^|| The Heart Hospital, London, England
^¶ Division of Cardiology, Memorial University, St. John's, Newfoundland, Canada

View larger version (16K): [in a new window]   Figure 1 Part of one of 11 autosomal-dominant families with arrhythmogenic right ventricular cardiomyopathy linked to 3p25 showing family members at high risk (n = 197), low risk (n = 92), and unknown (n = 78) status.

View larger version (16K): [in a new window]   Figure 2 Time to death or last follow-up (censored) in high-risk males and females with arrhythmogenic right ventricular cardiomyopathy linked to 3p25.

View larger version (16K): [in a new window]   Figure 3 (A) Time to death or last follow-up (censored) in 30 male subjects at high-risk for arrhythmogenic right ventricular cardiomyopathy linked to 3p25 who received implantable cardioverter-defibrillators (ICDs) and 36 matched control subjects. (B) Time to death or last follow-up (censored) in 18 female subjects at high risk for arrhythmogenic right ventricular cardiomyopathy linked to 3p25 who received ICDs and 22 matched control subjects.

View larger version (20K): [in a new window]   Figure 4 Time to first appropriate discharge or last follow-up (censored) for sustained ventricular tachycardia (VT) and for VT >240 beats/min in males who received an implantable cardioverter-defibrillator and time to death or last follow-up (censored) in matched controls with arrhythmogenic right ventricular cardiomyopathy linked to 3p25.