Economic effects of prolonged clopidogrel therapy after percutaneous coronary intervention
Patricia A. Cowper, PhD*, ,*,
Krishna Udayakumar, MD, MBA,
Michael H. Sketch, Jr, MD and
Eric D. Peterson, MD, MPH, FACC*,
* Outcomes Research and Assessment Group, Duke Clinical Research Institute
Duke University Medical Center, Durham, North Carolina
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Figure 1 Decision model subtree for no clopidogrel arm. A parallel subtree exists for the treatment arm. Circles = chance nodes; arrowheads = terminal nodes. Revasc = revascularization.
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Figure 2 Cost-effectiveness of prolonged clopidogrel therapy: sensitivity to variation in relative risk for myocardial infarction (MI). The cost per year of life saved is shown for values of relative risk for MI between 0 and 1. Solid line without symbols = all patients; line with triangles = high-risk patients; line with circles = low-risk patients. Baseline value of relative risk for MI is indicated by the vertical dotted line.
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Figure 3 Cost-effectiveness of prolonged clopidogrel therapy: sensitivity to variation in price of clopidogrel. The cost per year of life saved is shown for clopidogrel prices between $0 and $4 per day. Solid line without symbols = all patients; line with triangles = high-risk patients; line with circles = low-risk patients. Baseline value for daily price of clopidogrel is indicated by the vertical dotted line.
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Figure 4 Cost-effectiveness of prolonged clopidogrel therapy: sensitivity to variation in estimate of the reduction in life expectancy associated with myocardial infarction (MI). The cost per year of life saved is shown for a range of values of reduction in life expectancy subsequent to MI. Solid line without symbols = all patients; line with triangles = high-risk patients; line with circles = low-risk patients. Baseline value for reduction in life expectancy due to MI is indicated by the vertical dotted line.
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