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Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine

Raffi Bekeredjian, MD^*, Paul A. Grayburn, MD, FACC^,* and Ralph V. Shohet, MD^*

^* Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas
Baylor University Medical Center, Dallas, Texas

View larger version (18K): [in a new window]   Figure 1 Schematic representation of substance delivery using ultrasound-targeted microbubble destruction. An ultrasound contrast agent with an attached or incorporated bioactive substance is administered into the vasculature and will distribute throughout the capillaries. Ultrasound can then destroy microbubbles in the target region, thus releasing the transported substance into the surrounding tissue.