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Antagonism of selectin function attenuates microvascular platelet deposition and platelet-mediated myocardial injury after transient ischemia

José A. Barrabés, MD^*, David Garcia-Dorado, MD, FACC^*,*, Maribel Mirabet, PhD^*, Javier Inserte, PhD^*, Luis Agulló, PhD^*, Bernat Soriano, PharmD, Anna Massaguer, PhD, Ferran Padilla, MD^*, Rosa-Maria Lidón, MD^* and Jordi Soler-Soler, MD, FACC^*

^* Department of Cardiología, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Department of Medicina Nuclear, Hospital Universitari Vall d'Hebron, Barcelona, Spain
Department of Immunology Unit, IDIBAPS, Barcelona, Spain

View larger version (35K): [in a new window]   Figure 1 Bleeding time in series A (circles) and B (inverted triangles). p value: effect of fucoidan (repeated measures analysis of variance).

View larger version (15K): [in a new window]   Figure 2 Myocardial platelet content after 2 h of reperfusion.

View larger version (29K): [in a new window]   Figure 3 Peak hyperemic response at the left anterior descending coronary artery. p value: effect of fucoidan (repeated measures analysis of variance).

View larger version (38K): [in a new window]   Figure 4 Left ventricular end-diastolic pressure (LVEDP), developed pressure (LVdevP), and perfusion pressure (PP) throughout the experiments in isolated rat hearts. P value: effect of fucoidan (repeated measures analysis of variance). Solid circles = control (n = 8); open circles = fucoidan (n = 8).

View larger version (20K): [in a new window]   Figure 5 Lactate dehydrogenase (LDH) release after reperfusion in isolated hearts. P value: effect of fucoidan (repeated measures analysis of variance).