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J Am Coll Cardiol, 2005; 45:272-277, doi:10.1016/j.jacc.2004.09.059
© 2005 by the American College of Cardiology Foundation
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Independent and incremental prognostic value of early mitral annulus velocity in patients with impaired left ventricular systolic function

Mei Wang, MD, PhD, Gabriel Yip, MD, Cheuk-Man Yu, MD, FRACP, FRCP, Qing Zhang, MD, Yan Zhang, MD, Deko Tse, EN, Shun-Ling Kong, RN and John E. Sanderson, MD, FRCP, FACC*

Division of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China



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Figure 1 Kaplan-Meier demonstrating cardiac mortality in patients classified according to early diastolic mitral annular velocity (Em) <3 or Em ≥3 cm/s. Cum = cumulative.

 


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Figure 2 Incremental value of early diastolic mitral annular velocity (Em) <3 and early diastolic transmitral flow velocity (E)/Em >15 in predicting long-term (median 48 months) cardiac mortality. The addition of deceleration time (DT), E/Em, and Em resulted in significant incremental improvements in the predictive value of a model including clinical risk factors (age, ischemic heart disease, valvular heart disease, and heart failure): chi-square ({chi}2) = 25.0 with five degrees of freedom for clinical risk factors; chi-square = 29.4 with one degree of freedom for clinical risk factors plus DT ≤140 ms; chi-square = 33.0 with one degree of freedom for clinical risk factors plus DT ≤140 ms plus E/Em >15; and chi-square = 37.3 with one degree of freedom for clinical risk factors plus DT <140 ms plus E/Em >15 plus Em <3.

 





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