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Volumetric Quantitative Analysis of Tissue Characteristics of Coronary Plaques After Statin Therapy Using Three-Dimensional Integrated Backscatter Intravascular Ultrasound

Masanori Kawasaki, MD, PhD^_*,_*, Keiji Sano, MD, PhD^_*, Munenori Okubo, MD^_*, Haruko Yokoyama, MD^_*, Yoko Ito, MD, PhD^_*, Ichijiro Murata, MD, PhD^_*, Kunihiko Tsuchiya, MD, PhD^_*, Shinya Minatoguchi, MD, PhD^_*, Xiangrong Zhou, PhD, Hiroshi Fujita, PhD and Hisayoshi Fujiwara, MD, PhD^_*

^_* Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan
Department of Intelligent Image Information, Gifu University Graduate School of Medicine, Gifu, Japan

View larger version (69K): [in a new window]   Figure 1 (A) The three-dimensional (3D) color-coded maps of the coronary arterial plaques constructed by 3D integrated backscatter intravascular ultrasound. (B) The 3D color-coded maps of each characteristic. The number of voxels of each tissue characteristic was automatically calculated.

View larger version (120K): [in a new window]   Figure 2 Color-coded maps of the coronary arterial plaques constructed by three-dimensional (3D) integrated backscatter intravascular ultrasound imaging at baseline and after statin therapy. (A) At baseline, the plaque consisted of a large lipid core (blue), which is covered with a fibrous cap (green). (B) After statin therapies, the lipid core (blue) decreased and the fibrous area (green) increased. (C) Cut-out image of 3D color-coded map at baseline. There was a small lipid core (blue) in the center of the plaque. (D) Cut-out image of 3D color-coded map after statin therapy. Note the reduction in the lipid core. Red = high signal lesion; yellow = mixed lesion.