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Alcohol and the Cardiovascular System

Research Challenges and Opportunities

Diane L. Lucas, PhD^_*, Ricardo A. Brown, PhD^_*, Momtaz Wassef, PhD and Thomas D. Giles, MD^,_*

^_* Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland
Division of Heart and Vascular Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana

View larger version (18K): [in a new window]   Figure 1 Clinical consequences of ethanol consumption. ADH = alcohol dehydrogenase; ALDH = acetaldehyde dehydrogenase; CHD = coronary heart disease; CV = cardiovascular; IL = interleukin.

View larger version (22K): [in a new window]   Figure 2 Dose effects of ethanol consumption and potential mechanisms of cardiovascular response. CRP = C-reactive protein; HDL-C = high-density lipoprotein cholesterol; ICAM = intercellular adhesion molecule; IL = interleukin; LDL-C = low-density lipoprotein cholesterol; PKC = protein kinase C; VCAM = vascular cell adhesion molecule; VEGF = vascular endothelial growth factor.