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Serum Blood Urea Nitrogen as an Independent Marker of Subsequent Mortality Among Patients With Acute Coronary Syndromes and Normal to Mildly Reduced Glomerular Filtration Rates

Ajay J. Kirtane, MD^_*, David M. Leder, MD^_*, Sushrut S. Waikar, MD, Glenn M. Chertow, MD, MPH, Kausik K. Ray, MRCP, MD, Duane S. Pinto, MD^_*, Dimitrios Karmpaliotis, MD^_*, Andrew J. Burger, MD^_*, Sabina A. Murphy, MPH, Christopher P. Cannon, MD, Eugene Braunwald, MD, C. Michael Gibson, MS, MD^_*,_* for the TIMI Study Group

^_* Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusetts
Department of Medicine, University of California, San Francisco, San Francisco, California

View larger version (19K): [in a new window]   Figure 1 Kaplan-Meier survival estimates by blood urea nitrogen (BUN) level.

View larger version (14K): [in a new window]   Figure 2 Association of blood urea nitrogen with 30-day recurrent myocardial infarction and congestive heart failure.

View larger version (20K): [in a new window]   Figure 3 (A) Relation of blood urea nitrogen (BUN) and mortality estimates at six months stratified by estimated glomerular filtration rate (eGFR). (B) Relation of BUN and mortality estimates at six months stratified by serum creatinine. (C) Relation of BUN and mortality estimates at six months stratified by estimated creatinine clearance (CrCl).

View larger version (24K): [in a new window]   Figure 4 (A) Relation of blood urea nitrogen (BUN) and mortality estimates at six months stratified by Killip class. (B) Relation of BUN and mortality estimates at six months stratified by B-type natriuretic peptide (BNP).