Enhanced Shear-Induced Platelet Aggregation in Patients Who Experience Subacute Stent Thrombosis
A Case-Control Study
Nadine Ajzenberg, MD, PhD*,*,
Pierre Aubry, MD ,
Marie-Genevieve Huisse, MD*,
Agnés Cachier, MD,
Walid El Amara, MD,
Laurent J. Feldman, MD, PhD,
Dominique Himbert, MD,
Dominique Baruch, MD, PhD ,
Marie-Claude Guillin, MD, PhD* and
Ph. Gabriel Steg, MD
* Hématologie et Immunologie, Paris, France
Cardiologie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France
Hôpital de Bicêtre, Le Kremlin Bicêtre, France
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Figure 1 Platelet aggregation induced by (A) collagen, 2 µg/ml and (B) adenosine diphosphate (ADP), 3.2 µmol/l. Results are expressed as the maximal percent change in light transmittance from baseline at 5 min after addition of the agonist using platelet-poor plasma as a reference. Box and whisker plots show median value (horizontal lines), 25th and 75th percentiles (boxes), and 90th percentiles (error bars). *p < 0.01, **p < 0.001.
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Figure 2 Shear-induced platelet aggregation (SIPA) at (A) 200 s–1 and (B) 4,000 s–1. Results of aggregation are expressed as the percentage of disappearance of single platelets (DSP) as described in the Patients and Methods section. Box and whisker plots are outlined in Figure 1. *p < 0.01, **p < 0.001.
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