Additive Beneficial Effects of Fenofibrate Combined With Atorvastatin in the Treatment of Combined Hyperlipidemia
Kwang Kon Koh, MD, FACC*,*,
Michael J. Quon, MD, PhD ,
Seung Hwan Han, MD*,
Wook-Jin Chung, MD*,
Jeong Yeal Ahn, MD ,
Yiel-Hea Seo, MD,
In Suck Choi, MD* and
Eak Kyun Shin, MD*
* Department of Cardiology, Gachon Medical School, Incheon, Korea
Department of Laboratory Medicine, Gachon Medical School, Incheon, Korea
Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland.
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Figure 1 Fenofibrate alone or combined therapy significantly lowered triglycerides and increased high-density lipoprotein cholesterol levels when compared with atorvastatin alone. ANOVA = analysis of variance.
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Figure 2 Percent change in flow-mediated dilation from respective pretreatment values after treatment with atorvastatin alone, combined therapy, and fenofibrate alone. ANOVA = analysis of variance.
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Figure 3 Fenofibrate alone or combined therapy significantly lowered plasma fibrinogen levels relative to baseline measurements. Combined therapy significantly reduced levels more than atorvastatin alone. ANOVA = analysis of variance.
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Figure 4 Percent change in adiponectin levels (left) and in Quantitative Insulin-Sensitivity Check Index (QUICKI) (right) from respective pretreatment values after treatment with atorvastatin alone, combined therapy, and fenofibrate alone. ANOVA = analysis of variance.
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